CPI-444, Adenosine A2A receptor antagonist (TBI4101)
$171.00 – $693.00
CPI-444, Adenosine A2A receptor antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4101-5MG | Yes | 5 MG | $171.00 | |||
TBI4101-25MG | Yes | 25 MG | $693.00 |
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Description
Product Details
Formal Name: 7-(5-methylfuran-2-yl)-3-[[6-[[(3S)-oxolan-3-yl]oxymethyl]pyridine-2-yl]triazolo[4,5-d]pyrimidin-5-amine
Alternate Names: Ciforadenant
Molecular Formula: C20H21N7O3
Formula Weight: 407.43
CAS Number: 1202402-40-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Adenosine A2A receptor antagonist
Functions
CPI-444 (1202402-40-1) is a potent (Ki = 3.54 nM) and selective adenosine A2A receptor antagonist. It blocked the induction of cAMP induced by NECA in HEK-293 cells with an IC50 = 17.03 nM. CPI-444 monotherapy or in combination with anti-PD-1, anti-PD-L1, and anti-CTLA-4 induced T-cell-mediated tumor responses, inhibited tumor growth, and enabled antitumor immune memory. Currently in clinical trials for multiple cancers.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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