PKSI-527, Plasma kallikrein inhibitor (selective) (TBI2220)
$135.00 – $540.00
Plasma kallikrein inhibitor (selective)
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2220-5MG | Yes | 5 MG | $135.00 | |||
TBI2220-25MG | Yes | 25 MG | $540.00 |
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Description
Product Details
Formal Name: trans-4-Aminomethylcyclohexanecarbonyl-phenylalanyl-4-carboxymethylanilide, hydrochloride
Molecular Formula: C25H31N3O4·HCl
Formula Weight: 474.00
CAS Number: 128837-71-8
Purity: >98%
Formulation: powder
Solubility: Soluble in Water (up to 5 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Plasma kallikrein inhibitor (selective)
Functions
Selective inhibitor of plasma kallikrein (PLK) (Ki = 0.81 µM) that attenuates arthritis and renal damage in rats with adjuvant-induced arthritis. Its combination with NO donor GSNO in blood samples led to strong platelet inhibition and thrombolysis. Blocked PLK-dependent TGF-β activation and significantly reduced hepatic apoptosis and mortality in a mouse model of acute liver injury.
Application Procedures
First dissolved in Water (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in water may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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