Piperine, Up-regulator of skeletal muscle metabolism (TBI4607)
$45.00 – $126.00
Up-regulator of skeletal muscle metabolism
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4607-50MG | Yes | 50 MG | $45.00 | |||
TBI4607-250MG | Yes | 250 MG | $126.00 |
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Description
Product Details
Formal Name: 1-[5-(1,3-Benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine
Alternate Names: 1-Piperoylpiperidine
Molecular Formula: C17H19NO3
Formula Weight: 285.30
CAS Number: 94-62-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Up-regulator of skeletal muscle metabolism
Functions
Component of black pepper that activates TRPV1 (EC50 = 38 µM), inhibits MAO-A/B (Ki = 19.0 / 3.19 μM), and stimulates chloride currents through GABAA receptors (EC50 = 52.4 μM)1-3. At 20 mg/kg, piperine significantly lowers blood glucose in alloxan-induced diabetic mice4. Also modulates cytochrome P450 family members, inhibiting MDR1, CYP3A4, CYP2E1, CYP2C9 while also increasing their expression4-6. Exhibits anti-inflammatory and anti-cancer effects5. Increases the metabolic rate of resting muscle (fast twitch skeletal fibers) without affecting slow twitch or cardiac fibers via destabilization of the super-relaxed state of myosin heads7.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.
Additional information
SIZE (mg) | 250 MG, 50 MG |
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