Piericidin A, Mitochondrial complex I inhibitor; CoQ10 analog (TBI3467)
$81.00 – $252.00
Mitochondrial complex I inhibitor; CoQ10 analog
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3467-200UG | Yes | 200 µg | $81.00 | |||
TBI3467-1MG | Yes | 1 MG | $252.00 |
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Description
Product Details
Formal Name: 2-(10-hydroxy-3,7,9,11-tetramethyl-2,4,7,11-tridecatetraenyl)-5,6-dimethoxy-3-methyl-4-pyridinol
Alternate Names: Piericidin A1; Shaoguanmycin B; SN 198E; AR-054
Molecular Formula: C26H37NO4
Formula Weight: 415.60
CAS Number: 2738-64-9
Purity: >95%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Mitochondrial complex I inhibitor; CoQ10 analog
Functions
A potent inhibitor of the mitochondrial and bacterial type I NADH-ubiquinone oxidoreductase (complex I). Piericidin A is a ubiquinone analog which binds to the ubiquinone binding site of the enzyme. It is an extremely useful tool for exploring the role of complex I in mitochondrial function in both normal and pathophysiology. Prevents upregulation of GRP78 and induces cell death in glucose-deprived, etoposide-resistant HT-29 cells (IC50=7.7 nM).
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 1 MG, 200 µg |
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