P22077, USP7 inhibitor (TBI4125)
$117.00 – $450.00
USP7 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4125-10MG | Yes | 10 MG | $117.00 | |||
TBI4125-50MG | Yes | 50 MG | $450.00 |
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Description
Product Details
Formal Name: 1-(5-((2,4-Difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone
Molecular Formula: C12H7F2NO3S2
Formula Weight: 315.32
CAS Number: 1247819-59-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
USP7 inhibitor
Functions
P22077 is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50 = 8 µM) and the closely related USP47. It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a DNA damage response enzyme. P22077 inhibits neuroblastoma growth via induction of p53-mediated apoptosis. N-Myc was destabilized by P22077 inhibition of USP7 in human neuroblastoma cells. It was able to stabilize p53 levels in conjunction with an Mdm2 inhibitor (Nutlin-3, Cat# 10-1350) in HCT116 colorectal carcinoma cells.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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