Oxaprozin, NFkB inhibitor (TBI1128)

Description

Product Details

Formal Name: 4,5-Diphenyl-2-oxazolepropanoic acid

Molecular Formula: C₁₈H₁₅NO₃

Formula Weight: 293.32

CAS Number: 21256-18-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO

Storage: RT

Stability: ≥ 1 year.

 

Applications

NFkB inhibitor

 

Functions

Oxaprozin is a clinically useful non-steroidal anti-inflammatory drug.  In addition to typical NSAID COX inhibition, Oxaprozin may also exert anti-inflammatory effects via inhibition of the Akt/IKK/NF-kappaβ pathway. The compound is capable of inhibiting both anandamide hydrolase in neurons (IC50= 85 µmol/l), with consequent potent analgesic activity, and NF-kappaB activation in inflammatory cells (IC50 = 50 µmol/l).

 

Application Procedures

First dissolved in DMSO, then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

 

Additional information

SIZE (mg)	10 MG, 50 MG

TBI1128_Oxaprozin