Olaparib, PARP1 inhibitor (TBI2154)
$81.00 – $234.00
PARP1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2154-5MG | Yes | 5 MG | $81.00 | |||
TBI2154-25MG | Yes | 25 MG | $234.00 |
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Description
Product Details
Formal Name: 4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazine-1(2H)-one
Alternate Names: AZD-2281; KU-59436
Molecular Formula: C24H23FN4O3
Formula Weight: 434.47
CAS Number: 763113-22-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 33 mg/ml) or in Ethanol (up to 1.7 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
PARP1 inhibitor
Functions
A highly potent and selective PARP-inhibitor with IC₅₀ values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively. In a genetically engineered mouse model for BRCA1-associated breast cancer olaparib inhibited tumor growth and improved survival with no signs of toxicity. Synergizes with many other anticancer agents. Shows efficacy in colorectal cancers. Prevents house dust mite allergen-induced asthma in a mouse model.
Application Procedures
First dissolved in DMSO (up to 33 mg/ml) or in Ethanol (up to 1.7 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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