ODQ, Soluble guanylyl cyclase inhibitor (TBI1211)
$54.00 – $151.00
Soluble guanylyl cyclase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1211-5MG | Yes | 5 MG | $54.00 | |||
TBI1211-25MG | Yes | 25 MG | $151.00 |
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Description
Product Details
Formal Name: 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
Molecular Formula: C9H5N3O2
Formula Weight: 187.15
CAS Number: 41443-28-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 40 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Soluble guanylyl cyclase inhibitor
Functions
A potent and selective inhibitor of soluble guanylyl cyclase (sGC), IC50 = 20 nM). ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly. ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC. ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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