NSC-405020, MT1-MMP inhibitor (TBI1462)
$90.00 – $360.00
MT1-MMP inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1462-5MG | Yes | 5 MG | $90.00 | |||
TBI1462-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: 3,4-Dichloro-N-(1-methylbutyl)benzamide
Molecular Formula: C12H15NCl2O
Formula Weight: 260.15
CAS Number: 7497-07-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
MT1-MMP inhibitor
Functions
Membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity in vivo. (IC50 > 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2. Suppresses bone erosion in a c-Fos-deficient mouse model. Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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