Nitisinone, Tyrosine metabolism inhibitor (TBI4648)
$45.00 – $171.00
Tyrosine metabolism inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4648-50MG | Yes | 50 MG | $45.00 | |||
TBI4648-250MG | Yes | 250 MG | $171.00 |
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Description
Product Details
Formal Name: 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
Alternate Names: NTBC
Molecular Formula: C14H10F3NO5
Formula Weight: 329.23
CAS Number: 104206-65-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Tyrosine metabolism inhibitor
Functions
Inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD; IC50 = 40 nM and 173 nM) and is in clinical use for the treatment of hereditary tyrosinemia type 1. CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine – Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy. Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 2 months.
Additional information
SIZE (mg) | 250 MG, 50 MG |
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