NAcM-OPT, NEDD8 ligation inhibitor (TBI1636)
$99.00 – $270.00
NEDD8 ligation inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1636-5MG | Yes | 5 MG | $99.00 | |||
TBI1636-25MG | Yes | 25 MG | $270.00 |
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Description
Product Details
Formal Name: 1-Benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea
Molecular Formula: C23H29Cl2N3O
Formula Weight: 434.40
CAS Number: 2089293-61-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
NEDD8 ligation inhibitor
Functions
A potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro). It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M/UBC12 and DCN1, a subunit of a multiprotein E3 ligase for the ubiquitin-like protein NEDD8, an interaction which is essential for assembly of the multiprotein ligation complex. NAcM-OPT inhibits NEDD8 ligation in vitro and in cells (IC50=10 μM) and suppresses anchorage-independent growth of HCC95 cells and is highly selective with respect to other N-terminal acetyl protein binding sites.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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