Monastrol, Kinesin Eg5 and mitosis inhibitor (TBI2629)
$135.00 – $396.00
Kinesin Eg5 and mitosis inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2629-5MG | Yes | 5 MG | $135.00 | |||
TBI2629-25MG | Yes | 25 MG | $396.00 |
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Description
Product Details
Formal Name: 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester
Molecular Formula: C14H16N2O3S
Formula Weight: 292.35
CAS Number: 254753-54-3
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Kinesin Eg5 and mitosis inhibitor
Functions
Potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles. Does not affect other motor proteins or tubulin. Specifically inhibits the mitotic molecular motor kinesin Eg5, a motor protein required for spindle formation (IC50 = 14 μM). Mimics the effect of amyloid β on long term potentiation in a cellular model of learning and memory. Enhances regeneration of adult axons.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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