ML210, GPX4 inhibitor; Ferroptosis Inducer (TBI4002)
$153.00 – $522.00
GPX4 inhibitor; Ferroptosis Inducer
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4002-10MG | Yes | 10 MG | $153.00 | |||
TBI4002-50MG | Yes | 50 MG | $522.00 |
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Description
Product Details
Formal Name: (4-(Bis(4-chlorophenyl)methyl)piperazine-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone
Molecular Formula: C22H20Cl2N4O4
Formula Weight: 475.3
CAS Number: 1360705-96-9
Purity: >98%
Formulation: Powder
Solubility: Soluble in DMSO (up to 30 mg/ml)
Storage: RT
Stability: ≥ 1 year.
Applications
GPX4 inhibitor; Ferroptosis Inducer
Functions
ML210 inhibits glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron-catalyzed formation of free radicals from lipid peroxides. Exposure of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state to ML210 resulted in selective induction of ferroptosis. ML210 is selectively lethal to HRASg12v expressing cells (IC50 = 7.1 nM for BJeLR cells) compared to isogenic cells without HRASg12v (IC50 = 272 nM for BJeH-LT cells). LUHMES dopaminergic neurons are highly susceptible to ML210-induced ferroptosis.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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