Lycorine HCl, Protein synthesis inhibitor; SCAP degrader (TBI2608)
$81.00 – $243.00
Protein synthesis inhibitor; SCAP degrader
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI2608-10MG | Yes | 10 MG | $81.00 | |||
TBI2608-50MG | Yes | 50 MG | $243.00 |
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Description
Product Details
Formal Name: An alkaloid from Amaryllidaceae
Alternate Names: Galanthidine; Amarylline; Narcissine
Molecular Formula: C16H17NO4 • HCl
Formula Weight: 323.80
CAS Number: 2188-68-3
Purity: >98%
Formulation: powder
Solubility: Soluble in Water (up to 15 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Protein synthesis inhibitor; SCAP degrader
Functions
Arrests cell cycle at G2/M phase and induces apoptosis in tumor cells. Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice. Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription. Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 µM). A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.
Application Procedures
First dissolved in Water (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in water may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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