Lipofermata, Fatty acid transport protein 2 (FATP2) inhibitor (TBI3902)

Description

Product Details

Formal Name: 5-Bromo-5’phenylspiro[1H-indole-3,2’-3H-1,3,4-thiadiazole]-2-one;

Alternate Names: CB16.2

Molecular Formula: C₁₅H₁₀BrN₃OS

Formula Weight: 360.2

CAS Number: 297180-15-5

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 20 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

Fatty acid transport protein 2 (FATP2) inhibitor

 

Functions

Lipofermata is an inhibitor of fatty acid transport protein 2 (FATP2; IC50 = 4.84 µM). It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase.  It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease. Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.

 

Application Procedures

First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.

 

Additional information

SIZE (mg)	10 MG, 50 MG

TBI3902_Lipofermata