K-858, Kinesin Eg5 inhibitor (TBI1312)
$108.00 – $432.00
Kinesin Eg5 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1312-5MG | Yes | 5 MG | $108.00 | |||
TBI1312-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
Molecular Formula: C13H15N3O2S
Formula Weight: 277.35
CAS Number: 72926-24-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml)
Storage: RT
Stability: ≥ 1 year.
Applications
Kinesin Eg5 inhibitor
Functions
Selective mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM) which acts in an ATP-noncompetitive manner. It is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K858 blocks centrosome separation, activates the spindle checkpoint and induces mitotic arrest accompanied by the formation of monopolar spindles. Displays no effect on microtubule polymerization. Selectively displays antiproliferative effects via induction of mitotic cell death in cancer cells over nontransformed cells.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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