JIB-04, pan-JUMONJI histone demethylase inhibitor (TBI1618)
$108.00 – $378.00
pan-JUMONJI histone demethylase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1618-5MG | Yes | 5 MG | $108.00 | |||
TBI1618-25MG | Yes | 25 MG | $378.00 |
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Description
Product Details
Formal Name: (E)-5-Chloro-2-(2-(phenyl(pyridine-2-yl)methylene)hydrazinyl)pyridine
Molecular Formula: C17H13ClN4
Formula Weight: 308.76
CAS Number: 199596-05-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
pan-JUMONJI histone demethylase inhibitor
Functions
A novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model. Suppresses translation initiation and enhances mTOR inhibitor sensitivity. Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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