IWP-4, Wnt inhibitor (TBI3370)
$126.00 – $585.00
Wnt inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3370-5MG | Yes | 5 MG | $126.00 | |||
TBI3370-25MG | Yes | 25 MG | $585.00 |
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Description
Product Details
Formal Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Molecular Formula: C23H20N4O3S3
Formula Weight: 496.60
CAS Number: 686772-17-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 0.5 mg/ml, with warming)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Wnt inhibitor
Functions
Potent Wnt pathway inhibitor (IC50 = 25 nM in cells that exhibit constitutive Wnt pathway activation) that targets Porcupine (a membrane-bound O-acyltransferase), preventing critical Wnt ligand palmitoylation. Also acts as an ATP-competitive inhibitor of mutant (M82F) Casein Kinase 1δ (IC50 = 142 nM). Inhibits growth and migration of cancer cell lines such as HT29, Panc1, and MDA-MB-2312,. Inhibits osteogenic differentiation. When used with CHIR-99021 (#MC-1279), induces cardiac differentiation by blocking expression of pluripotency markers and upregulating cardiac transcription factors.
Application Procedures
First dissolved in DMSO (up to 0.5 mg/ml, with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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