Indoximod, IDO modulator / tryptophan mimetic (TBI4569)
$36.00 – $99.00
IDO modulator / tryptophan mimetic
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4569-50MG | Yes | 50 MG | $36.00 | |||
TBI4569-250MG | Yes | 250 MG | $99.00 |
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Description
Product Details
Formal Name: 1-Methyl-D-tryptophan
Molecular Formula: C12H14N2O2
Formula Weight: 218.25
CAS Number: 110117-83-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (greater than 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
IDO modulator / tryptophan mimetic
Functions
Indoximod is a modulator of indoleamine 2,3-dioxygenase (IDO) activity. IDO can be used by tumors to avoid elimination by the host immune response, thus inhibition of IDO is an interesting cancer therapeutic option. Indoximod is not a direct inhibitor of IDO, but instead targets the IDO gene leading to downstream effects. IDO-mediated catabolism of tryptophan inhibits the immunoregulatory kinases mTOR and PKC5. This is relieved by Indoximod acting as a potent tryptophan mimetic restoring mTOR and PKC signaling.
Application Procedures
First dissolved in DMSO (greater than 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 250 MG, 50 MG |
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