2GBI, Hv1 channel blocker (TBI3127)
$90.00 – $180.00
Hv1 channel blocker
| SKU | Stock | SIZE (mg) | Price | Quantity | ||
|---|---|---|---|---|---|---|
| TBI3127-50MG | Yes | 50 MG | $90.00 | |||
| TBI3127-250MG | Yes | 250 MG | $180.00 |
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Description
Product Details
Formal Name: 2-Guanidinobenzimidazole
Molecular Formula: C8H9N5
Formula Weight: 175.19
CAS Number: 5418-95-1
Purity: >95%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming)
Storage: RT
Stability: ≥ 1 year.
Applications
Hv1 channel blocker
Functions
A selective and state-dependent blocker of voltage-gated proton channels (Hv1). 2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side. Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Additional information
| SIZE (mg) | 250 MG, 50 MG |
|---|
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