IMR-1, Notch transcriptional activation inhibitor (TBI3601)
$108.00 – $432.00
Notch transcriptional activation inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI3601-5MG | Yes | 5 MG | $108.00 | |||
TBI3601-25MG | Yes | 25 MG | $432.00 |
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Description
Product Details
Formal Name: 2-[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid ethyl ester
Molecular Formula: C15H15NO5S2
Formula Weight: 353.41
CAS Number: 310456-65-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 9 mg/ml with warming)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Notch transcriptional activation inhibitor
Functions
Inhibitor of Mastermind Recruitment-1 (IMR-1) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription. IC50=26 µM (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethylester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 µM (in vitro assay). Binding of IMR-1 to NTC is non-covalent and reversible.
Application Procedures
First dissolved in DMSO (up to 45 mg/ml) or in Ethanol (up to 9 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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