Importazole, Importin-b-mediated nuclear import blocker (TBI1412)
$90.00 – $360.00
Importin-b-mediated nuclear import blocker
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1412-5MG | Yes | 5 MG | $90.00 | |||
TBI1412-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine
Alternate Names: IPZ
Molecular Formula: C20H22N4
Formula Weight: 318.43
CAS Number: 662163-81-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
Importin-b-mediated nuclear import blocker
Functions
Specifically inhibits importin-β-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export. When added to cells during mitosis it impairs the release of an importin-β cargo probe and causes defects in spindle assembly. Inhibition of importin-β function is most likely mediated by blocking its interaction with RanGTP. It is an important new tool to probe the function of the importin-β/RanGTP pathway. Cell permeable
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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