Ibudilast, Neuroinflammation inhibitor (PDE pan-inhibitor) (TBI2236)
$72.00 – $243.00
Neuroinflammation inhibitor (PDE pan-inhibitor)
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2236-5MG | Yes | 5 MG | $72.00 | |||
TBI2236-25MG | Yes | 25 MG | $243.00 |
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Description
Product Details
Formal Name: 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine
Alternate Names: 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridine-3-yl 1-propanone; KC-404; AV411; MN-166
Molecular Formula: C14H18N2O
Formula Weight: 230.31
CAS Number: 50847-11-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
Neuroinflammation inhibitor (PDE pan-inhibitor)
Functions
Phosphodiesterase inhibitor with some selectivity for PDE4 and 5. (IC50s= 53, 35, 48,12 and10 μM for PDE 1a, 2, 3, 4 and 5 respectively). Acts as a cerebral vasodilator by selectively inducing a cGMP-independent relaxation of the intracranial vertebrobasilar artery. Attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma via PKA signaling. A glial cell activation inhibitor. Enhances morphine analgesia and attenuates tolerance and withdrawaI. Orally active and crosses the blood-brain barrier.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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