I-BET762, BET Bromodomain inhibitor; Suppresses Myc transcription (TBI4122)
$126.00 – $531.00
BET Bromodomain inhibitor; Suppresses Myc transcription
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4122-5MG | Yes | 5 MG | $126.00 | |||
TBI4122-25MG | Yes | 25 MG | $531.00 |
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Description
Product Details
Formal Name: (4S)- 6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide
Alternate Names: GSK525762
Molecular Formula: C22H22ClN5O2
Formula Weight: 423.90
CAS Number: 1260907-17-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
BET Bromodomain inhibitor; Suppresses Myc transcription
Functions
I-BET762 is a potent inhibitor of the BET family of bromodomains with no activity at bromodomains BAZ2B, SP140, ATAD2, CREBBO, and PCAF.1,2 IC50’s for H4Ac peptide displacement: BRD2 = 32.5nM, BRD3 = 42.4nM, BRD4 = 36.1nM. It was able to suppress proinflammatory proteins by macrophage, block acute inflammation in mice1, and suppressed the inflammatory function of T cells. Inhibition of BET bromodomains results in downregulation of Myc transcription, an important oncogene.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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