HC-067047, TRPV4 blocker (TBI1480)
$104.00 – $414.00
TRPV4 blocker
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1480-5MG | Yes | 5 MG | $104.00 | |||
TBI1480-25MG | Yes | 25 MG | $414.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
Molecular Formula: C26H28F3N3O2
Formula Weight: 471.51
CAS Number: 883031-03-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
TRPV4 blocker
Functions
Potent reversible and selective TRPV4 antagonist. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels. Increases functional bladder capacity and reduces micturition frequency in mice and rats with cystitis. Inhibits brain edema in middle cerebral artery occlusion mice. Induces an increase in core body temperature accompanied by increased oxygen consumption in Wistar rats. Active in vivo.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “HC-067047, TRPV4 blocker (TBI1480)”
You must be logged in to post a review.
Reviews
There are no reviews yet.