GW1100, GPR40 antagonist (TBI4516)
$90.00 – $306.00
GPR40 antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4516-5MG | Yes | 5 MG | $90.00 | |||
TBI4516-25MG | Yes | 25 MG | $306.00 |
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Description
Product Details
Formal Name: 1-(4-Ethoxycarbonylphenyl-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone
Molecular Formula: C27H25FN4O4S
Formula Weight: 520.59
CAS Number: 306974-70-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 2 mg/ml) or in DMF (up to 5 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
GPR40 antagonist
Functions
Selective antagonist of GPR40. GW1100 inhibits GRP40-mediated Ca2+ increases stimulated GW9508 or linoleic acid (pIC50 = 5.99 for either agonist). The effects of GPR40 activation on insulin secretion in cells are also blocked by the addition of GW1100. GW1100 does not influence calcium mobilization mediated by GPR120.
Application Procedures
First dissolved in DMSO (up to 2 mg/ml) or in DMF (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or DMF may be stored at -20° for up to 3 months. Dilutions into aqueous media are not stable and should be used within one working day.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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