GSK583, RIP2 kinase inhibitor (TBI4761)
$72.00 – $270.00
RIP2 kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4761-10MG | Yes | 10 MG | $72.00 | |||
TBI4761-50MG | Yes | 50 MG | $270.00 |
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Description
Product Details
Formal Name: 6-tert-Butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine
Molecular Formula: C20H19FN4O2S
Formula Weight: 398.40
CAS Number: 1346547-00-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
RIP2 kinase inhibitor
Functions
GSK583 (1346547-00-9) is a highly selective and potent inhibitor of RIP2 kinase, IC50 = 5 nM human and IC50 = 2 nM rat. It also potently inhibits isolated RIP3 kinase (IC50 = 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 10 MG, 50 MG |
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