GSK-J1, JMJ H3K27 Demethylase inhibitor (cell impermeable) (TBI1393)
$135.00 – $540.00
JMJ H3K27 Demethylase inhibitor (cell impermeable)
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1393-5MG | Yes | 5 MG | $135.00 | |||
TBI1393-25MG | Yes | 25 MG | $540.00 |
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Description
Product Details
Formal Name: N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine
Molecular Formula: C22H23N5O2
Formula Weight: 389.46
CAS Number: 1373422-53-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
JMJ H3K27 Demethylase inhibitor (cell impermeable)
Functions
Potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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