GSK-3787, PPARd antagonist (TBI1001)
$90.00 – $360.00
PPARd antagonist
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1001-5MG | Yes | 5 MG | $90.00 | |||
TBI1001-25MG | Yes | 25 MG | $360.00 |
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Description
Product Details
Formal Name: 4-Chloro-N-(2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide
Molecular Formula: C15H12ClF3N2O3S
Formula Weight: 392.80
CAS Number: 188591-46-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
PPARd antagonist
Functions
Selective and irreversible antagonist of peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) (plC50 = 6.6), but not PPARα or ɣ. It covalently binds to Cys 249 in the PPARβ/δ binding site1. When applied topically, GSK-3787 showed efficacy against an inflammatory skin disease resembling psoriasis in mice. Suppresses colorectal cancer tumorigenesis in Apc(δ580) mice.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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