GSK-1016790A, TRPV4 channel activator (TBI1198)
$122.00 – $392.00
TRPV4 channel activator
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1198-5MG | Yes | 5 MG | $122.00 | |||
TBI1198-25MG | Yes | 25 MG | $392.00 |
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Description
Product Details
Formal Name: (N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide
Molecular Formula: C28H32Cl2N4O6S2
Formula Weight: 655.62
CAS Number: 942206-85-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 10 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
TRPV4 channel activator
Functions
A novel and potent TRPV4 channel agonist. GSK1016790A induced Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. It is 300-fold more potent than 4α-PDD and is a valuable tool for investigating the role of TRPV4 in physiological processes.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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