GRL-0667, SARS-CoV-2 papain-like protease (PLpro, Nsp3) inhibitor (TBI4963)

$171.00$666.00

SARS-CoV-2 papain-like protease (PLpro, Nsp3) inhibitor

SKU: TBI4963 Category:
SKUStock SIZE (mg) PriceQuantity
TBI4963-5MG Yes 5 MG $171.00
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TBI4963-25MG Yes 25 MG $666.00
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Description

Product Details

Formal Name: 1-[(R)-1-(1-Naphthyl)ethyl)]-4-[3,4-(methylenedioxy)benzylamino]carbonylpiperidine

Molecular Formula: C26H28N2O3

Formula Weight: 416.50

CAS Number: 1234195-91-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or Ethanol (up to 15 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

SARS-CoV-2 papain-like protease (PLpro, Nsp3) inhibitor

 

Functions

GRL-0667 is a potent (IC50 = 320 nM) noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). GRL-0667 inhibited SARS-CoV viral replication in Vero E6 cells with no cytotoxicity (EC50 = 9.1 µM).

 

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or Ethanol (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Additional information

SIZE (mg)

25 MG, 5 MG

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