Gimeracil, Dihydropyrimidine dehydrogenase inhibitor (TBI4601)
$90.00 – $297.00
Dihydropyrimidine dehydrogenase inhibitor
| SKU | Stock | SIZE (mg) | Price | Quantity | ||
|---|---|---|---|---|---|---|
| TBI4601-25MG | Yes | 25 MG | $90.00 | |||
| TBI4601-100MG | Yes | 100 MG | $297.00 |
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Description
Product Details
Formal Name: 5-Chloro-4-hydroxypyridine-2(1H)-one
Molecular Formula: C5H4ClNO2
Formula Weight: 145.54
CAS Number: 103766-25-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Dihydropyrimidine dehydrogenase inhibitor
Functions
Gimeracil is a dihydropyrimidine dehydrogenase (DPD) inhibitor. DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU). Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs. Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
| SIZE (mg) | 25 MG, 100 MG |
|---|
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