Ganetespib, HSP90 Inhibitor (TBI4474)
$117.00 – $450.00
HSP90 Inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI4474-5MG | Yes | 5 MG | $117.00 | |||
TBI4474-25MG | Yes | 25 MG | $450.00 |
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Description
Product Details
Formal Name: 3-(2,4-Dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one
Alternate Names: STA-9090
Molecular Formula: C20H20N4O3
Formula Weight: 364.40
CAS Number: 888216-25-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
HSP90 Inhibitor
Functions
Ganetespib is an inhibitor of heat shock protein 90 (IC50 = 19 nM, canine C2 malignant mast cells; 4 nM, canine BR malignant mast cells) binding to the N-terminal ATP site. It displayed potent cytotoxicity against a panel of 57 transformed cell lines of both hematologic and solid tumors with IC50’s between 14 and 280 nM. Ganetespib enhanced T-cell-mediated killing of human melanoma cells and potentiated responses to anti-CTLA4 and anti-PD1 therapy via upregulation of interferon response genes. In multiple clinical trials for various cancers.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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