Fruquintinib, Potent and selective inhibitor of VEGFR kinase (TBI4784)
$135.00 – $459.00
Potent and selective inhibitor of VEGFR kinase
| SKU | Stock | SIZE (mg) | Price | Quantity | ||
|---|---|---|---|---|---|---|
| TBI4784-5MG | Yes | 5 MG | $135.00 | |||
| TBI4784-25MG | Yes | 25 MG | $459.00 |
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Description
Product Details
Formal Name: 6-(6,7-Dimethoxyquinazolin-4-yl)oxy-N,2-dimethyl-1-benzofuran-3-carboxamide
Alternate Names: HMPL-013
Molecular Formula: C21H19N3O4
Formula Weight: 393.40
CAS Number: 1194506-26-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Potent and selective inhibitor of VEGFR kinase
Functions
Fruquintinib is a potent and highly selective inhibitor of VEGFR kinase (IC50’s: VEGFR1= 33 nM, VEGFR2 = 35 nM, VEGFR3 = 0.5 nM). It potently inhibited VEGF/VEGFR signaling and cell proliferation in HUVECs and HLECs and prevented angiogenesis in vitro. Fruquintinib is currently is several clinical trials against metastatic colorectal cancer and nonsquamous non-small-cell lung cancer.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.
Additional information
| SIZE (mg) | 25 MG, 5 MG |
|---|
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