Epacadostat, IDO1 inhibitor (TBI4499)
$81.00 – $270.00
IDO1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4499-5MG | Yes | 5 MG | $81.00 | |||
TBI4499-25MG | Yes | 25 MG | $270.00 |
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Description
Product Details
Formal Name: N-(3-Bromo-4-fluorophenyl)-N’-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide
Alternate Names: INCB024360
Molecular Formula: C11H13BrFN7O4S
Formula Weight: 438.20
CAS Number: 1204669-58-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
IDO1 inhibitor
Functions
Epacadostat is a potent (IC50 = 10nM) and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1) with no activity at IDO2 or TDO. It restored tryptophan levels and significantly impaired kynurenine generation in CT26 colon carcinoma (IC50 = 76 nM) and PAN02 pancreatic carcinoma (IC50 = 27 nM) cells. Epacadostat increases the number and activity of tumor-infiltrating lymphocytes as well as increasing the ratio of effector T cells to regulatory T cells. Because of these immune system enhancing properties, it is being investigated as a synergistic agent for use with other immuno-oncology agents such as anti-PD-1 and anti-CTL4 antibodies.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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