Enzastaurin, PKC inhibitor (TBI2132)
$108.00 – $367.00
PKC inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2132-5MG | Yes | 5 MG | $108.00 | |||
TBI2132-25MG | Yes | 25 MG | $367.00 |
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Description
Product Details
Formal Name: 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Alternate Names: LY-317615
Molecular Formula: C32H29N5O2
Formula Weight: 515.61
CAS Number: 170364-57-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 7 mg/ml with warming)
Storage: -20°C
Stability: ≥ 1 year.
Applications
PKC inhibitor
Functions
Potent and selective PKCβ inhibitor. IC50 = 6, 39, 83 and 110 nM, for PKCβ, PKCα, PKCγ and PKCε respectively. Induces apoptosis in multiple myeloma cell lines via inhibition of the AKT signaling pathway. Induces mitotic missegregation and preferential cytotoxicity in colorectal cancer cells with chromosomal instability. Attenuates ampheta-mine-stimulated dopamine efflux. Inhibits blood-brain barrier leakiness in a mouse model.
Application Procedures
First dissolved in DMSO (up to 7 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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