Enasidenib, Mutant isocitrate dehydrogenase 2 (IDH2) inhibitor (TBI4660)
$99.00 – $405.00
Mutant isocitrate dehydrogenase 2 (IDH2) inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4660-5MG | Yes | 5 MG | $99.00 | |||
TBI4660-25MG | Yes | 25 MG | $405.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 2-Methyl-1-[[4-[6(trifluoromethyl)-2-pyridinyl]-6-[[2-(trifluoromethyl)-4-pyridinyl]amino]-1,3,5-triazin-2-yl]amino]-2-propanol
Alternate Names: AG-221
Molecular Formula: C19H17F6N7O
Formula Weight: 473.38
CAS Number: 1446502-11-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Mutant isocitrate dehydrogenase 2 (IDH2) inhibitor
Functions
Enasidenib is a potent (IC50’s = 100 nM IDH2R140Q homodimer, 30 nM IDH2R140Q/WT heterodimer and 10 nM IDH2R172K/WT heterodimer) and selective inhibitor of mutant isocitrate dehydrogenase 2 (IDH2). It suppressed the production of the oncometabolite (R)-2-Hydroxyglutarate (a competitive inhibitor of αKG-dependent dioxygenases which leads to epigenetic dysregulation) and induced cellular differentiation in primary human IDH2 mutation-positive acute myeloid leukemia cells. Recently approved for clinical use by the FDA.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “Enasidenib, Mutant isocitrate dehydrogenase 2 (IDH2) inhibitor (TBI4660)”
You must be logged in to post a review.
Reviews
There are no reviews yet.