Decoyinine, GMP synthase inhibitor (TBI5149)

Description

Product Details

Formal Name: 4′,5′-Didehydro-1′-C-(hydroxymethyl)-adenosine

Alternate Names: Angustmycin A; U-7984

Molecular Formula: C₁₁H₁₃N₅O₄

Formula Weight: 279.3

CAS Number: 2004-04-8

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (50 mg/ml); or Water (35 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

GMP synthase inhibitor

Functions

Non-competitive and reversible inhibitor of GMP synthase (GMPS, IC₅₀=17.3 µM).  GMPS was shown to be a positive regulator of invasiveness in melanoma cells and decoyinne reduced invasion of melanoma cells by 30%. Decoyinine reduces intracellular levels of GMP, GDP and GTP. Numerous studies of decoyinine in bacteria have been performed showing that guanylates play key roles in bacterial growth, cell wall biosynthesis, sporulation, and pathogenicity.

Application Procedures

First dissolved in DMSO (50 mg/ml) or in Ethanol (35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or water may be stored at -20°C for up to 1 month.

Research use only.

Additional information

Datasheet:

TBI5149_Decoyinine_datasheet

MSDS:

TBI5149_Decoyinine_MSDS_2024

Research use only.