DBIC, DNMT3B S-nitrosylation inhibitor (TBI5161)
$135.00 – $540.00
DNMT3B S-nitrosylation inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI5161-5MG | Yes | 5 MG | $135.00 | |||
TBI5161-25MG | Yes | 25 MG | $540.00 |
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Description
Product Details
Formal Name: (E)-N’-(3,4-Dihydroxybenzylidene)-1H-benzo[d]imidazole-5-carbohydrazide
Molecular Formula: C15H12N4O3
Formula Weight: 296.30
CAS Number: 487026-67-5
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (30 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
DNMT3B S-nitrosylation inhibitor
Functions
Specifically inhibits S-nitrosylation of DNA methyltransferase 3B (DNMT3B) at low concentrations, IC50≤100 nM, without affecting its enzymatic activity. Treatment with DBIC prevents nitric oxide-induced conversion of human colonic adenoma to adenocarcinoma in vitro. Treatment with DBIC strongly attenuates tumor development in a mouse model of carcinogenesis triggered by inflammation-induced NO production. DNMT3B-mediated DNA methylation is regulated by S-nitrosylaton and DBIC represents a new useful tool for studying this system. A negative control compound, DBIC-neg2 (Cat # MC-5162) is also available.
Application Procedures
First dissolved in DMSO (30 mg/ml), then diluted to aqueous buffer. S Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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