Cytarabine, DNA damaging agent; antiviral (TBI1268)
$72.00 – $162.00
DNA damaging agent; antiviral
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1268-500MG | Yes | 500 MG | $72.00 | |||
TBI1268-2G | Yes | 2 G | $162.00 |
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Description
Product Details
Formal Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
Alternate Names: Arabinocytidine; Cytosine β-D-Arabinofuranoside; U-19920A; Ara-C
Molecular Formula: C9H13N3O5
Formula Weight: 243.20
CAS Number: 147-94-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 12 mg/ml), or in Water (up to 24 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
DNA damaging agent; antiviral
Functions
A nucleoside analog that interferes with DNA synthesis and transcription, particularly in tumor cells. Cellular enzymes convert it to its phosphorylated form, Ara-CTP, which disrupts DNA and RNA synthesis when polymerases attempt to incorporate it. For the same reasons, it is also employed as an antiviral. It inhibits proliferation of a variety of leukemic cell lines (IC50s 16-72 nM), but is used primarily against acute myeloid leukemia (AML).
Application Procedures
First dissolved in DMSO (up to 12 mg/ml), or in Water (up to 24 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or water may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 2 G, 500 MG |
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