CCT251236, HSF1 inhibitor (TBI4410)
$162.00 – $585.00
CCT251236, HSF1 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4410-5MG | Yes | 5 MG | $162.00 | |||
TBI4410-25MG | Yes | 25 MG | $585.00 |
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Description
Product Details
Formal Name: N-[5-(2,3-Dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide
Molecular Formula: C32H32N4O5
Formula Weight: 552.60
CAS Number: 1693731-40-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
HSF1 inhibitor
Functions
An inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP72 induction, IC50 = 40 nM HSPA1A induction). It displayed efficacy in a human ovarian carcinoma xenograft mouse model (SK-OV 3 cells) and inhibited migration of WM266.4 melanoma cells @ 100 nM. CCT251236 showed high affinity for the protein pirin (Ki = 28 nM), but this target was not shown conclusively to be the cause of the anticancer activity. It also showed efficacy in vitro against primary patient-derived myeloma cells and H929 human myeloma xenograft models.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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