Carfilzomib, Proteasome inhibitor (TBI1477)
$90.00 – $297.00
Proteasome inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1477-5MG | Yes | 5 MG | $90.00 | |||
TBI1477-25MG | Yes | 25 MG | $297.00 |
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Description
Product Details
Formal Name: (αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]- L-Phenylalaninamide
Alternate Names: PR-171
Molecular Formula: C40H57N5O7
Formula Weight: 719.93
CAS Number: 868540-17-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 80 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Proteasome inhibitor
Functions
A potent and irreversible proteasome inhibitor. Synthetic analog of the microbial product epoxomcin. Compared to bortezomib it displays equal potency but greater selectivity for the chymotrypsin-like activity of the proteasome. In cell culture it is more cytotoxic than bortezomib and hematologic tumor cells exhibit greater sensitivity than solid tumor cells. Treatment of cells with carfilzomib results in the accumulation of proteasome substrates and induction of cell cycle arrest and/or apoptosis. Effective against multiple myeloma. Active in vivo.
Application Procedures
First dissolved in DMSO (up to 80 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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