C16, PKR kinase inhibitor (TBI1329)
$122.00 – $486.00
PKR kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI1329-5MG | Yes | 5 MG | $122.00 | |||
TBI1329-25MG | Yes | 25 MG | $486.00 |
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Description
Product Details
Formal Name: 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
Molecular Formula: C13H8N4OS
Formula Weight: 268.30
CAS Number: 608512-97-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 15 mg/ml, with warming).
Storage: -20°C
Stability: ≥ 2 years.
Applications
PKR kinase inhibitor
Functions
Inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM). Inhibits ER stress-induced neuronal damage. Reduces brain PKR activation in vivo. Prevents apoptosis and IL-1β production in an acute excitotoxic and neuroinflammatory rat model. Prevents β-amyloid peptide-induced inflammation in primary murine mixed co-cultures. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 15 mg/ml, with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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