Bosutinib, Src/Abl kinase inhibitor (TBI2122)
$72.00 – $252.00
Src/Abl kinase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI2122-5MG | Yes | 5 MG | $72.00 | |||
TBI2122-25MG | Yes | 25 MG | $252.00 |
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Description
Product Details
Formal Name: 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
Alternate Names: SKI-606
Molecular Formula: C26H29Cl2N5O3
Formula Weight: 530.60
CAS Number: 380843-75-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Src/Abl kinase inhibitor
Functions
Bosutinib is an ATP-competitive dual Src/Abl kinase inhibitor (IC50 = 1 nM). It potently inhibits the apoptosis-linked STE20 kinases but does not inhibit Kit or PDGFR. Bosutinib was found to inhibit 16 of 18 imatinib-resistant mutant forms of Bcr-Abl expressed in murine myeloid cell lines, but did not inhibit T315I and V299L mutants. Enhances retinoic acid-induced differentiation of HL-60 leukemia cells. Suppresses migration and invasion of human breast cancer cells (IC50 = 250 nM which is also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells).
Application Procedures
First dissolved in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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