Binimetinib, MEK1/2 inhibitor (TBI4789)
$70.00 – $207.00
MEK1/2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI4789-5MG | Yes | 5 MG | $70.00 | |||
TBI4789-25MG | Yes | 25 MG | $207.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 6-(4-Bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
Alternate Names: ARRY-162; MEK162
Molecular Formula: C17H15BrF2N4O3
Formula Weight: 441.23
CAS Number: 606143-89-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
MEK1/2 inhibitor
Functions
Binimetinib (606143-89-9) is a potent (IC50 = 12 nM) and selective allosteric inhibitor of MEK1/2. Recently approved by the FDA for treatment of melanoma in combination with Encorafenib. Binimetinib has had limited success as monotherapy but has shown promise in combination with other chemotherapeutic agents.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “Binimetinib, MEK1/2 inhibitor (TBI4789)”
You must be logged in to post a review.
Reviews
There are no reviews yet.