BIBR1532, Telomerase inhibitor (TBI3920)
$108.00 – $351.00
Telomerase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3920-5MG | Yes | 5 MG | $108.00 | |||
TBI3920-25MG | Yes | 25 MG | $351.00 |
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Description
Product Details
Formal Name: (E)-2-(3-(Naphthalen-2-yl)but-2-enamido)benzoic acid
Molecular Formula: C21H17NO3
Formula Weight: 331.40
CAS Number: 321674-73-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Telomerase inhibitor
Functions
Non-competitive specific inhibitor of telomerase (IC50 = 93 nM), targeting telomerase reverse transcriptase (hTERT). Induces apoptosis in MCF-7 breast cancer cells and breast cancer stem cells and affected the epithelial mesenchymal transition in breast cancer stem cells. BIBR1532 eliminated pancreatic stem cells via DNA damage and apoptosis in primary patient-derived samples. It significantly inhibited cell proliferation and induced apoptosis in acute myeloid leukemia stem cells.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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