Baricitinib, Immunosuppressant; JAK1/2 inhibitor (TBI3893)
$86.00 – $180.00
Immunosuppressant; JAK1/2 inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
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TBI3893-5MG | Yes | 5 MG | $86.00 | |||
TBI3893-25MG | Yes | 25 MG | $180.00 |
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Description
Product Details
Formal Name: 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile
Alternate Names: INCB 028050; LY3009104
Molecular Formula: C16H17N7O2S
Formula Weight: 371.4
CAS Number: 1187594-09-7
Purity: >95%
Formulation: powder
Solubility: Soluble in DMSO (up to at least 30 mg/ml) or DMF (up to at least 50 mg/ml)
Storage: RT
Stability: ≥ 2 years.
Applications
Immunosuppressant; JAK1/2 inhibitor
Functions
Baricitinib, approved by the FDA for two inflammatory disorders, rheumatoid arthritis and alopecia areata, selectively inhibits Janus kinase 1 (IC50 = 5.9 nM) and 2 (5.7 nM), over 3 (0.56 µM). It thereby blocks JAK/STAT signaling, reducing cytokine release and suppressing the innate and adaptive immune systems. Was recently shown to significantly improve COVID-19 symptoms in a preliminary human trial, presumably through suppression of the cytokine release syndrome (“cytokine storm”) induced by SARS-CoV-2 infection.
Application Procedures
First dissolved in DMSO (up to at least 30 mg/ml) or DMF (up to at least 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
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