AZD 6244, ERK inhibitor (TBI4509)

Description

Product Details

Alternate Names: ARRY-142886; Selumetinib

Molecular Formula: C₁₇H₁₅BrClFN₄O₃

Formula Weight: 457.68

CAS Number: 606143-52-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

 

Applications

ERK inhibitor

 

Functions

AZD6244 is a potent, selective, and non-ATP competitive inhibitor of MEK1/2 (IC50 MEK1 = 14 nM) and ERK 1/2 phosphorylation (IC50 = 10 nM). AZD 6244 is in clinical trials for treating various cancers.

 

Application Procedures

First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 2 months.

Additional information

SIZE (mg)	10 MG, 50 MG

TBI4509_AZD 6244