AT7519 HCl, CDK inhibitor (TBI4859)

Description

Product Details

Formal Name: 4-[(2,6-Dichlorobenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamide hydrochloride

Molecular Formula: C₁₆H₁₇Cl₂N₅O₂·HCl

Formula Weight: 418.7

CAS Number: 902135-91-5

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (> 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years

Applications

CDK inhibitor

Functions

Potent CDK inhibitor. Inhibits CDKs 1,2,4,5,6, and 9 (IC₅₀s respectively: 210 nM, 47 nM, 100 nM, 13 nM, 170 nM, and <10 nM). Active in multiple human cancer cell lines. Has also been found to be a human RORγt agonist.

Application Procedures

First dissolved in DMSO (>25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Additional information

Datasheet:

TBI4859_AT7519 HCl_datasheet

MSDS:

TBI4859_AT7519 HCl_MSDS

Research use only.