AS-8351, KDM5B histone demethylase inhibitor (TBI1597)
$90.00 – $360.00
KDM5B histone demethylase inhibitor
SKU | Stock | SIZE (mg) | Price | Quantity | ||
---|---|---|---|---|---|---|
TBI1597-5MG | Yes | 5 MG | $90.00 | |||
TBI1597-25MG | Yes | 25 MG | $360.00 |
- Description
- Terms
- Additional information
- Documents
- Reviews (0)
Description
Product Details
Formal Name: 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
Alternate Names: NSC-51355
Molecular Formula: C17H13N3O2
Formula Weight: 291.30
CAS Number: 796-42-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
Storage: -20°C
Stability: ≥ 2 years.
Applications
KDM5B histone demethylase inhibitor
Functions
AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.
Application Procedures
First dissolved in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Additional information
SIZE (mg) | 25 MG, 5 MG |
---|
Be the first to review “AS-8351, KDM5B histone demethylase inhibitor (TBI1597)”
You must be logged in to post a review.
Reviews
There are no reviews yet.